IMMUNOSENESCENCE, GUT DYSBIOSIS, AND CHRONIC KIDNEY DISEASE: INTERPLAY AND IMPLICATIONS FOR CLINICAL MANAGEMENT

Immunosenescence, gut dysbiosis, and chronic kidney disease: Interplay and implications for clinical management

Immunosenescence refers to the immune system changes observed in individuals over 50 years old, characterized by diminished immune response and chronic inflammation.Recent investigations have highlighted similar immune alterations in patients with reduced kidney function.The immune system and kidney function have been found to be closely interconne

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A Comparison of the Evaporative Emissions Performance of Light-Duty Vehicles under US Tier 3 and China 6 Test Conditions

To further improve air quality in China, especially ozone and fine particulate matter (PM2.5), additional reductions of volatile organic compounds (VOCs) are needed.Evaporative emissions from internal combustion engines (ICE) and hybrid vehicles are known to be an important source of VOCs in urban cities, which can be efficiently reduced through th

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Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy

Abstract Transcription-coupled nucleotide excision repair (TC-NER) is an important genome maintenance system that preferentially removes DNA lesions on the transcribed strand of actively transcribed genes, including non-coding genes.TC-NER involves lesion recognition by the initiation complex consisting of RNA polymerase II (Pol II) and Cockayne sy

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